GO:0071889 molecular_function 14-3-3 protein binding
| PAG Title | GO:0071889 molecular_function 14-3-3 protein binding |
| PAG ID | TAX029728 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. |
| Species | Homo sapiens |
| nCoCo Score | 156 |
| Base PAG ID | TAX029728 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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